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Warframe Operation: Plague Star Guide (2025): Farming, Recommended Warframes and Weapons Guide This is a guide video for the Warframe Plague Star operation, which has been re-released after 2 years. It introduces the event period, how to acquire items, recommended Warframe and weapon builds, and efficient farming methods through actual gameplay footage.
Warframe Operation: Plague Star Guide (2025): Farming, Recommended Warframes and Weapons Guide
1. ⭐ Plague Star Operation Rerun: Period and Basic Information
  • ✅ Plague Star Operation (Forma Operation) Rerun after 2 years
  • ✅ Event Period: 2 weeks
  • ✅ Operation method can be checked in the in-game event tab (same as before)

ItemDescription
Event Period2 weeks
Operation MethodCheck in the in-game event tab
00:03 - 00:25
1. ⭐ Plague Star Operation Rerun: Period and Basic Information
  • ✅ Plague Star Operation (Forma Operation) Rerun after 2 years
  • ✅ Event Period: 2 weeks
  • ✅ Operation method can be checked in the in-game event tab (same as before)

ItemDescription
Event Period2 weeks
Operation MethodCheck in the in-game event tab
00:39 - 01:25
2. 🛠️ Core Item Acquisition and Reward Information
  • ✅ Core Items: Eidolon Infection Barrier, Infection Catalyst
  • ✅ Infection Catalyst: Obtain blueprint from the Dojo Bio Lab
  • ✅ Eidolon Infection Barrier: Exchange blueprint at the Operation Supply Squad during the event period
  • ✅ Pure Forma: Obtainable without exchange, same as in the past
  • ✅ New Reward: Omni Forma (limited to 1 exchange)

ItemAcquisition Source
Infection CatalystDojo Bio Lab
Eidolon Infection BarrierOperation Supply Squad
Omni FormaOperation Supply Squad (limited to 1)
01:26 - 01:48
3. 💰 Chi Points and Additional Reward Information
  • ✅ Past Chi Points can be carried over
  • ✅ Chi Points required for Forma exchange: 3000 (no change)
  • ✅ No limit to Chi Point acquisition: Pure Forma obtainable by repeatedly participating in the event

ItemDescription
Chi Points for Forma Exchange3000
Chi Point Acquisition LimitNone
01:49 - 02:23
4. 🎁 New and Rerun Reward Information
  • ✅ New Rewards: Hemocyte Sigil, Glyph, Noggle
  • ✅ Rerun Rewards: Past event-related Arcanes, Ghoul Saw
  • ✅ Includes Cetus Wisp

Reward TypeDetails
New RewardsHemocyte Sigil, Glyph, Noggle
Rerun RewardsArcanes, Ghoul Saw, Cetus Wisp
02:24 - 02:41
5. Quest and Difficulty Information
  • ✅ Plague Star Operation quest added to the console during the event period
  • ✅ Difficulty: 3 levels (top 2 levels require Barrier and Catalyst)
  • ✅ Barrier and Catalyst changed to an admission ticket concept

DifficultyRequired Items
Top 2Barrier, Catalyst
02:42 - 02:59
6. Item Consumption and Relic Acquisition Information
  • ✅ Consumes 1 Barrier and 1 Catalyst upon entering the quest
  • ✅ Relics can be acquired as quest rewards (including Caliban Prime Relics)

ItemDescription
Item Consumption1 Barrier, 1 Catalyst each
Relic AcquisitionIncludes Caliban Prime Relics
03:00 - 03:25
7. Farming Efficiency and Preparations
  • ✅ Can farm Pure Forma and new Prime simultaneously
  • ✅ If the equipment is good, it can be cleared in about 12 minutes in Steel Path solo play
  • ✅ Nax can be acquired

ItemDescription
Clear TimeAround 12 minutes (Steel Path Solo)
Farming GoalPure Forma, New Prime, Nax
03:26 - 03:42
8. Hemocyte Weakness Change and Preparation
  • ✅ Hemocyte Weakness: Slash, Fire
  • ✅ Weakness mismatch when using builds from 2 years ago

CategoryWeakness
Before ChangeCorrosion
After ChangeSlash, Fire
04:02 - 05:33
9. Recommended Warframe: Nova Build and Weapon Introduction
  • ✅ Warframe: Nova
  • ✅ Arcane Shard: Red Tau (Ability Duration Enhancement)
  • ✅ 4th Ability: Can switch between tap/hold acceleration
  • ✅ Weapon: Pyrana Prime (Fire addition, Recoil reduction)
  • ✅ Melee Weapon: Vastilok (Shattering Impact, Attack Speed Enhancement) or Salpha

WarframeRecommended Weapon
NovaPyrana Prime, Vastilok (or Salpha)
05:34 - 06:55
10. Actual Gameplay Footage: Stage 1 ~ Stage 2 Guide
  • ✅ Steel Path Gameplay Footage
  • ✅ Stage 1: Retrieve Toxic Containers from Underground (Set Waypoint at Entrance)
  • ✅ Stage 2: Activate Mixer and Defend for 3 Minutes (Utilize Crew Call)

StageGoal
Stage 1Retrieve Toxic Containers
Stage 2Activate Mixer and Defend
06:56 - 08:30
11. Stage 3: Drone Carrying Tips
  • ✅ Utilize Nova's 3rd Ability (Wormhole)
  • ✅ Drone Carrying Distance Reduction Tip: Wait at a Specific Location
  • ✅ Warframes Capable of Carrying Drones: Volt, Loki, Wisp
  • ✅ Drone Stop Prevention: Stay within 50m of the Drone

WarframeAbility
NovaWormhole (3rd)
VoltSpeed (2nd)
LokiInvisibility (3rd)
WispHaste Mote (1st)
08:31 - 09:35
12. Stage 4: Hemocyte Guide and Clear
  • ✅ Stage 4: Hemocyte appears after killing Infested
  • ✅ Remove armor with melee weapon, then attack weakness
  • ✅ Hemocyte Search and Retrieval
  • ✅ Clear in about 12 minutes

StageGoal
Stage 4Kill Hemocyte
09:36 - 10:14
13. Hemocyte Search Usage
  • ✅ Dojo Decoration: Plague Star Trophy Production
  • ✅ Helminth Feed: Protein Supplement

UsageDescription
Dojo DecorationPlague Star Trophy
HelminthProtein Supply
10:15 - 11:40
14. Recommended Warframe: Volt Build and Boar Prime Introduction
  • ✅ Warframe: Volt
  • ✅ Arcane Shard: Yellow Tau (Ability Cast Speed), Blue Tau (Armor), Red Tau (Ability Strength)
  • ✅ Subsumed Ability: Mirage 3rd (Damage Buff)
  • ✅ Weapon: Boar Prime (Fire, Infested Faction Damage)

WarframeRecommended Weapon
VoltBoar Prime
11:41 - 12:39
15. Volt Usage Tips and Pyrana Prime Reassessment
  • ✅ Volt: Easy to carry drones (using 2nd ability)
  • ✅ Volt: Enhanced Melee Speed and Reload Speed
  • ✅ Boar Prime: Not subject to Hemocyte damage cap
  • ✅ Pyrana Prime: Boar Prime has more stable firepower

WarframeAdvantage
VoltDrone Carrying, Melee Speed Enhancement
Boar PrimeNot subject to damage cap
12:40 - 13:38
16. Recommended Warframe: Titania Build and Usage
  • ✅ Warframe: Titania
  • ✅ Helminth: Subsume Ammo Efficiency
  • ✅ Utilize 4th Ability (Razorfly)
  • ✅ Recommended for Multi-Play (Drone cannot be carried)
  • ✅ Steel Path: No Energy Gear Cooldown

WarframeCharacteristic
TitaniaRazorfly, Recommended for Multi-Play
13:39 - 14:18
17. Final Recommendation and Closing
  • ✅ Volt + (Boar Prime or previous Hemocyte recommended weapon) combination recommended
  • ✅ Titania: Consider if there is no Hemocyte synergy weapon

WarframeReason for Recommendation
VoltDrone Carrying, Speed Buff
TitaniaAlternative if there is no Hemocyte synergy weapon
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